Engaging innate immunity in perioperative strategies

Mechanisms, biomarkers, and clinical observations

Leonie Helder • Boek • paperback

• Samenvatting
  Free download at https://doi.org/10.54195/9789465150123
  
  This thesis investigates the complex immune response to surgical stress, focusing on the interplay between tissue damage, anesthesia, and immune regulation. The research highlights how surgery triggers immune activation and suppression, with significant implications for postoperative complications, including inflammation, infection, and cancer recurrence. It explores the roles of inflammatory mechanisms, epigenetic changes, and metabolic adaptations in innate immune cells, and how these factors affect healing and host-defense against pathogens after surgery. Key findings demonstrate that surgery and anesthesia modulate innate immune functions, with factors such as pain and the release of DAMPs (Damage-Associated Molecular Patterns) playing significant roles. The research identifies critical mechanisms behind immune dysregulation, including mitochondrial dysfunction and changes in antigen presentation, impacting leukocyte function and immune homeostasis. This dysregulation can hinder recovery, leading to excessive inflammation or immune suppression, which increases risks for infections and delayed wound healing. The thesis emphasizes that while the surgical stress response cannot be fully prevented, its impact can be minimized through low-impact surgeries and strategic choices in anesthesia and medication. Furthermore, prehabilitation and trained immunity offer potential for enhancing immune resilience to surgical stress. The thesis discusses novel avenues for developing personalized therapeutic strategies and targeted interventions to monitor and reduce immune dysregulation, ultimately improving surgical outcomes and patient recovery.
• Productinformatie
  Binding : Paperback
  Distributievorm : Boek (print, druk)
  Formaat : 170mm x 240mm
  Aantal pagina's : 247
  Uitgeverij : Radboud University Press
  ISBN : 9789465150123
  Datum publicatie : 12-2024
  
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